USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P10909 USC-OGP 2-DE database:  P10909 P10909 General information about the entry View entry in simple text format Entry name CLUS_HUMAN Primary accession number P10909 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Clusterin; AltName: Full=Aging-associated gene 4 protein; AltName: Full=Apolipoprotein J; Short=Apo-J; AltName: Full=Complement cytolysis inhibitor; Short=CLI; AltName: Full=Complement-associated protein SP-40,40; AltName: Full=Ku70-binding protein 1; AltName: Full=NA1/NA2; AltName: Full=Testosterone-repressed prostate message 2; Short=TRPM-2; Contains: RecName: Full=Clusterin beta chain; AltName: Full=ApoJalpha; AltName: Full=Complement cytolysis inhibitor a chain; Contains: RecName: Full=Clusterin alpha chain; AltName: Full=ApoJbeta; AltName: Full=Complement cytolysis inhibitor b chain; Flags: Precursor;. Gene name Name=CLU Synonyms=APOJ, CLI, KUB1 ORFNames=AAG4 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0102: pI=4.60; Mw=39101 SPOT OGP-0104: pI=4.73; Mw=38805 SPOT OGP-0113: pI=4.84; Mw=37642 SPOT OGP-0114: pI=4.83; Mw=37263 SPOT OGP-0119: pI=4.95; Mw=36515 Cross-references UniProtKB/Swiss-Prot P10909; CLUS_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name CLUS_HUMAN Primary accession number P10909 Secondary accession number(s) B2R9Q1 B3KSE6 P11380 P11381 Q2TU75 Q5HYC1 Q7Z5B9 Sequence was last modified on  July 1, 1989 (version 1) Annotations were last modified on  March 15, 2017 (version 197) Name and origin of the protein Description RecName: Full=Clusterin; AltName: Full=Aging-associated gene 4 protein; AltName: Full=Apolipoprotein J; Short=Apo-J; AltName: Full=Complement cytolysis inhibitor; Short=CLI; AltName: Full=Complement-associated protein SP-40,40; AltName: Full=Ku70-binding protein 1; AltName: Full=NA1/NA2; AltName: Full=Testosterone-repressed prostate message 2; Short=TRPM-2; Contains: RecName: Full=Clusterin beta chain; AltName: Full=ApoJalpha; AltName: Full=Complement cytolysis inhibitor a chain; Contains: RecName: Full=Clusterin alpha chain; AltName: Full=ApoJbeta; AltName: Full=Complement cytolysis inhibitor b chain; Flags: Precursor; Gene name Name=CLU Synonyms=APOJ, CLI, KUB1 ORFNames=AAG4 Encoded on Name=CLU; Synonyms=APOJ, CLI, KUB1; ORFNames=AAG4 Keywords Alternative splicing; Apoptosis; Chaperone; Complement pathway; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Immunity; Innate immunity; Membrane; Microsome; Mitochondrion; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Secreted; Signal; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M25915; AAA35692.1; ALT_INIT; mRNA EMBL M63379; AAB06507.1; -; Genomic_DNA EMBL M63376; AAB06507.1; JOINED; Genomic_DNA EMBL M63377; AAB06507.1; JOINED; Genomic_DNA EMBL M63378; AAB06507.1; JOINED; Genomic_DNA EMBL M64722; AAB06508.1; ALT_SEQ; mRNA EMBL AK093399; BAG52708.1; -; mRNA EMBL AK313870; BAG36598.1; ALT_INIT; mRNA EMBL CR599675; -; NOT_ANNOTATED_CDS; mRNA EMBL BX648414; CAI45990.1; -; mRNA EMBL AY341244; AAP88927.1; ALT_INIT; Genomic_DNA EMBL AF311103; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL BC010514; AAH10514.1; ALT_INIT; mRNA EMBL BC019588; AAH19588.1; ALT_INIT; mRNA EMBL BU150467; -; NOT_ANNOTATED_CDS; mRNA EMBL J02908; AAA51765.1; -; mRNA EMBL M74816; AAA60321.1; -; mRNA EMBL L00974; AAA60567.1; -; Genomic_DNA EMBL X14723; CAA32847.1; ALT_INIT; mRNA EMBL AY513288; AAT08041.1; ALT_INIT; mRNA CCDS CCDS47832.1; -. [P10909-1]; . PIR S43646; A41386; . RefSeq NP_001822.3; NM_001831.3. [P10909-1]; . RefSeq XP_006716347.1; XM_006716284.2. [P10909-2]; . UniGene Hs.436657; -; . ProteinModelPortal P10909; -; . BioGrid 107603; 141; . DIP DIP-37546N; -; . IntAct P10909; 51; . MINT MINT-3007494; -; . STRING 9606.ENSP00000315130; -; . iPTMnet P10909; -; . PhosphoSitePlus P10909; -; . BioMuta CLU; -; . DMDM 116533; -; . DOSAC-COBS-2DPAGE P10909; -; . OGP P10909; -; . REPRODUCTION-2DPAGE IPI00291262; -; . SWISS-2DPAGE P10909; -; . EPD P10909; -; . MaxQB P10909; -; . PaxDb P10909; -; . PeptideAtlas P10909; -; . PRIDE P10909; -; . DNASU 1191; -; . Ensembl ENST00000316403; ENSP00000315130; ENSG00000120885. [P10909-1]; . Ensembl ENST00000405140; ENSP00000385419; ENSG00000120885. [P10909-1]; . Ensembl ENST00000523500; ENSP00000429620; ENSG00000120885. [P10909-1]; . GeneID 1191; -; . KEGG hsa:1191; -; . UCSC uc003xfw.3; human. [P10909-1]; . CTD 1191; -; . DisGeNET 1191; -; . GeneCards CLU; -; . GeneCards MIR6843; -; . HGNC HGNC:2095; CLU; . HPA CAB000476; -; . HPA CAB016253; -; . HPA HPA000572; -; . MIM 185430; gene; . neXtProt NX_P10909; -; . OpenTargets ENSG00000120885; -; . PharmGKB PA26620; -; . eggNOG ENOG410IHRB; Eukaryota; . eggNOG ENOG410YYKB; LUCA; . GeneTree ENSGT00530000063668; -; . HOVERGEN HBG006908; -; . InParanoid P10909; -; . KO K17252; -; . OMA MKFYARV; -; . OrthoDB EOG091G05R5; -; . PhylomeDB P10909; -; . TreeFam TF333030; -; . Reactome R-HSA-114608; Platelet degranulation; . Reactome R-HSA-166665; Terminal pathway of complement; . Reactome R-HSA-6803157; Antimicrobial peptides; . ChiTaRS CLU; human; . GeneWiki Clusterin; -; . GenomeRNAi 1191; -; . PMAP-CutDB P10909; -; . PRO PR:P10909; -; . Proteomes UP000005640; Chromosome 8; . Bgee ENSG00000120885; -; . CleanEx HS_CLU; -; . ExpressionAtlas P10909; baseline and differential; . Genevisible P10909; HS; . GO GO:0097440; C:apical dendrite; IDA:Alzheimers_University_of_Toronto; . GO GO:0072562; C:blood microparticle; IDA:UniProtKB; . GO GO:0009986; C:cell surface; IDA:UniProtKB; . GO GO:0042583; C:chromaffin granule; IEA:UniProtKB-SubCell; . GO GO:0005737; C:cytoplasm; IDA:Alzheimers_University_of_Toronto; . GO GO:0005829; C:cytosol; IEA:UniProtKB-SubCell; . GO GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0031012; C:extracellular matrix; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:0005615; C:extracellular space; IDA:UniProtKB; . GO GO:0005794; C:Golgi apparatus; ISS:ParkinsonsUK-UCL; . GO GO:0005622; C:intracellular; IEA:GOC; . GO GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell; . GO GO:0005739; C:mitochondrion; IDA:BHF-UCL; . GO GO:0097418; C:neurofibrillary tangle; IDA:Alzheimers_University_of_Toronto; . GO GO:0005634; C:nucleus; IEA:UniProtKB-SubCell; . GO GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB; . GO GO:0031093; C:platelet alpha granule lumen; TAS:Reactome; . GO GO:0043234; C:protein complex; IDA:UniProtKB; . GO GO:0034366; C:spherical high-density lipoprotein particle; IDA:BHF-UCL; . GO GO:0051087; F:chaperone binding; ISS:ParkinsonsUK-UCL; . GO GO:0051787; F:misfolded protein binding; IDA:UniProtKB; . GO GO:0031625; F:ubiquitin protein ligase binding; IDA:UniProtKB; . GO GO:0019730; P:antimicrobial humoral response; TAS:Reactome; . GO GO:0000902; P:cell morphogenesis; IDA:Alzheimers_University_of_Toronto; . GO GO:0032286; P:central nervous system myelin maintenance; IMP:Alzheimers_University_of_Toronto; . GO GO:0051131; P:chaperone-mediated protein complex assembly; IDA:Alzheimers_University_of_Toronto; . GO GO:0061077; P:chaperone-mediated protein folding; IDA:UniProtKB; . GO GO:0006956; P:complement activation; TAS:ProtInc; . GO GO:0006958; P:complement activation; classical pathway; IEA:UniProtKB-KW GO GO:0045087; P:innate immune response; IEA:UniProtKB-KW; . GO GO:0097193; P:intrinsic apoptotic signaling pathway; IDA:UniProtKB; . GO GO:0006629; P:lipid metabolic process; NAS:ProtInc; . GO GO:0001774; P:microglial cell activation; IDA:Alzheimers_University_of_Toronto; . GO GO:0061518; P:microglial cell proliferation; IDA:Alzheimers_University_of_Toronto; . GO GO:1905907; P:negative regulation of amyloid fibril formation; TAS:ARUK-UCL; . GO GO:1902430; P:negative regulation of beta-amyloid formation; IDA:Alzheimers_University_of_Toronto; . GO GO:0060548; P:negative regulation of cell death; IMP:ARUK-UCL; . GO GO:1905892; P:negative regulation of cellular response to thapsigargin; IMP:ARUK-UCL; . GO GO:1905895; P:negative regulation of cellular response to tunicamycin; IMP:ARUK-UCL; . GO GO:1902230; P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; IMP:BHF-UCL; . GO GO:0032463; P:negative regulation of protein homooligomerization; IDA:ARUK-UCL; . GO GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; TAS:ARUK-UCL; . GO GO:1903573; P:negative regulation of response to endoplasmic reticulum stress; IMP:ARUK-UCL; . GO GO:0002576; P:platelet degranulation; TAS:Reactome; . GO GO:0043065; P:positive regulation of apoptotic process; IMP:UniProtKB; . GO GO:1902004; P:positive regulation of beta-amyloid formation; ISS:Alzheimers_University_of_Toronto; . GO GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IMP:UniProtKB; . GO GO:1902998; P:positive regulation of neurofibrillary tangle assembly; IMP:Alzheimers_University_of_Toronto; . GO GO:1901216; P:positive regulation of neuron death; IDA:Alzheimers_University_of_Toronto; . GO GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:UniProtKB; . GO GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IDA:Alzheimers_University_of_Toronto; . GO GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IMP:UniProtKB; . GO GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:UniProtKB; . GO GO:1902949; P:positive regulation of tau-protein kinase activity; IMP:Alzheimers_University_of_Toronto; . GO GO:0032760; P:positive regulation of tumor necrosis factor production; IDA:Alzheimers_University_of_Toronto; . GO GO:0017038; P:protein import; IDA:Alzheimers_University_of_Toronto; . GO GO:0050821; P:protein stabilization; IDA:UniProtKB; . GO GO:1900221; P:regulation of beta-amyloid clearance; IDA:Alzheimers_University_of_Toronto; . GO GO:1901214; P:regulation of neuron death; IDA:Alzheimers_University_of_Toronto; . GO GO:1902847; P:regulation of neuronal signal transduction; IMP:Alzheimers_University_of_Toronto; . GO GO:0001836; P:release of cytochrome c from mitochondria; IC:BHF-UCL; . GO GO:0051788; P:response to misfolded protein; IDA:BHF-UCL; . GO GO:0009615; P:response to virus; IEP:UniProtKB; . GO GO:0043691; P:reverse cholesterol transport; TAS:BHF-UCL; . InterPro IPR016016; Clusterin; . InterPro IPR000753; Clusterin-like; . InterPro IPR016015; Clusterin_C; . InterPro IPR033986; Clusterin_CS; . InterPro IPR016014; Clusterin_N; . PANTHER PTHR10970; PTHR10970; 1; . PANTHER PTHR10970:SF5; PTHR10970:SF5; 1; . Pfam PF01093; Clusterin; 1; . PIRSF PIRSF002368; Clusterin; 1; . SMART SM00035; CLa; 1; . SMART SM00030; CLb; 1; . PROSITE PS00492; CLUSTERIN_1; 1; . PROSITE PS00493; CLUSTERIN_2; 1; .

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